Search results for "CA [MG]"

Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.

2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…

Talete di Mileto

2020

Alan Mathison Turing

2020

Wartość społeczna w międzysektorowych projektach zrównoważonego rozwoju. Studium przypadku

2020

W artykule podjęto tematykę współpracy międzysektorowej realizującej projekty zrównoważonego rozwoju. Jego celem jest wskazanie wartości społecznej kreowanej przez partnerów wspólnego przedsięwzięcia. Postawiono pytanie o to, jaka wartość społeczna jest tworzona we współpracy podmiotów różnych sektorów gospodarki w ramach projektów zrównoważonych oraz jaką rolę w procesie tworzenia wartości społecznej odgrywa sama współpraca międzysektorowa. W części badawczej pracy zaprezentowano studia przypadków wybranych projektów. Jak wynika z przeprowadzonych badań, wykorzystanie wzajemnych potencjałów pozwala na bardziej efektywne tworzenie i użytkowanie wartości przez szerszy krąg interesariuszy. Do…

Oscillatory periodic pattern dynamics in hyperbolic reaction-advection-diffusion models

2022

In this work we consider a quite general class of two-species hyperbolic reaction-advection-diffusion system with the main aim of elucidating the role played by inertial effects in the dynamics of oscillatory periodic patterns. To this aim, first, we use linear stability analysis techniques to deduce the conditions under which wave (or oscillatory Turing) instability takes place. Then, we apply multiple-scale weakly nonlinear analysis to determine the equation which rules the spatiotemporal evolution of pattern amplitude close to criticality. This investigation leads to a cubic complex Ginzburg-Landau (CCGL) equation which, owing to the functional dependence of the coefficients here involve…

Photocatalytic nano-composite architectural lime mortar for degradation of urban pollutants under solar and visible (interior) light

2017

Abstract Recent advances in nano-technology and nano-additives can give enhanced properties to natural hydraulic lime (NHL), creating a multifunctional material. We have prepared a novel nanocomposite, made of a commercial mortar with 1 wt% and 5 wt% added titania nanoparticles (NPs). These TiO 2 NPs are themselves doped with 1 mol% silver, to give the material enhanced photocatalytic and antimicrobial properties. The Ag-doped TiO 2 NPs were made from a simple, costs effective, aqueous green nanosynthesis process, and the end material only contains 0.01–0.05% Ag. As this mortar is intended to both combat atmospheric pollution, and create more durable/lower maintenance building facades (plas…

Over-dispersion in Oral Health: The state of art of statistical methodology

2011

Disticha moralia

Ms. il·luminat Títol obtingut de la rúbrica (f. 1r) Col·lació: Paper, f. iii (paper actual) + 73 + iii (paper actual) ; reclams verticals cada 10 fulls ; caixa d'escriptura 212 x 130 mm (f. 2r) Composició: Escrit a línia tirada a 30 línies (f. 2r) Escriptura: Humanística antiqua Decoració: Caplletra amb bianchi girari i pa d'or (f.1r); rùbrica en tinta vermella i calderons en blau i vermell alternant Enquadernació: Mudèjar gofrada amb decoració de rodes. Restaurada en la dècada del 1970 Origen: Escrit problement a Itàlia en els anys centrals del segle XV, tot atenent l'escriptura utilitzada i el paper emprat (Briquet, filigrana semblant als números: 5572, 5576 i 5577). En un bifoli situat a…

Innovative Approaches for Organizing an Inclusive Optics and Photonics Conference in Virtual Format

2023

The COVID pandemic is forcing the renewal of scientific conferences, offering opportunities to introduce technological and inclusive developments. Our analysis focuses on the implementation of inclusive practices for female and early-career researchers in a virtual scientific conference. This organization approach was applied in the XIII Spanish Optical Meeting (RNO2021), which was also characterized by avatars interacting in an online metaverse. The effectiveness of inclusive policies and novel technological tools was evaluated using the participation data and a post-conference survey. Our study reveals the high impact of inclusive actions and a strong interest in the scientific community …

Genetic variability at αs2-casein gene in Girgentana dairy goat breed

2014

Casein genes are highly polymorphic and the high degree of variability has qualitative and quantitative effects on milk composition thereby affecting chemical, physical and technological properties of goat milk. The aim of this work was to evaluate the genetic polymorphisms of the αs2-casein (CSN1S2) gene in the endangered Girgentana dairy goat breed in order to assess the genotypes distribution, as it is known genotype influences technological and nutritional milk properties. The study was performed on 207 sample of Girgentana goat breed, analysed with different PCR protocols. The most frequent alleles was A (0.722), followed by F (0.225), C (0.051) and E (0.002) while B, D and 0 alleles w…